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Abstract #5570

Brain response to stop signal task in lifelong Premature Ejaculation patients compared to healthy subjects

Lan Zhang1, Xuejuan Yang1, Ming Gao2,3, Lin Liu1, Peng Liu1, Jinbo Sun1, Wei Qin1, and Jie Tian1

1Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaan xi, China, 2Department of Urology, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi, China, 3The ART Center, Maternal and Child Health Care Hospital of Shaanxi Province, Xi’an, China

Life-long premature ejaculation (LPE) is a common male sexual dysfunction. Previous studies revealed ejaculation-related control mechanisms in the brain. However, whether this control network changes in patients with LPE is unclear. A stop signal test was used in this study. A study of task-related functional MRI found there was a significant difference in neural network activation between healthy controls and LPE patients during go process. This study indicates a neural network abnormality in LPE patients, which provides novel reference for understanding the neural mechanism of LPE.

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