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Abstract #5576

Verifying the Reliability of Steady-State Free Precession fMRI in Detecting Oxygen Saturation Changes in Rat C6 Glioma

Hao Chen1, Junwei Zhang1, Zhen Jiang1, Jin Xu1, Qiqi Chen1, Siying Wang2, and Junkang Shen1

1Second affiliated hospital of Soochow University, Suzhou, China, 2Philips Healthcare, Shanghai, China

In this study, we aim to verify the reliability of steady-state free precession (SSFP) technique for detecting oxygen saturation level changes in functional MRI (fMRI). We compared SSFP fMRI image signals in rat glioma with pO2 values measured directly using MRI compatible fiber-optic microprobes, and we found that their temporal variations resembled each other. Therefore, SSFP fMRI, as a non-invasive imaging technique, can be used to reveal the location of re-oxygenation hence hypoxia in tumor.

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