Abstract #5576

Verifying the Reliability of Steady-State Free Precession fMRI in Detecting Oxygen Saturation Changes in Rat C6 Glioma

Hao Chen¹, Junwei Zhang¹, Zhen Jiang¹, Jin Xu¹, Qiqi Chen¹, Siying Wang², and Junkang Shen¹

¹Second affiliated hospital of Soochow University, Suzhou, China, ²Philips Healthcare, Shanghai, China

In this study, we aim to verify the reliability of steady-state free precession (SSFP) technique for detecting oxygen saturation level changes in functional MRI (fMRI). We compared SSFP fMRI image signals in rat glioma with pO₂ values measured directly using MRI compatible fiber-optic microprobes, and we found that their temporal variations resembled each other. Therefore, SSFP fMRI, as a non-invasive imaging technique, can be used to reveal the location of re-oxygenation hence hypoxia in tumor.

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