In this study, we aim to verify the reliability of steady-state free precession (SSFP) technique for detecting oxygen saturation level changes in functional MRI (fMRI). We compared SSFP fMRI image signals in rat glioma with pO2 values measured directly using MRI compatible fiber-optic microprobes, and we found that their temporal variations resembled each other. Therefore, SSFP fMRI, as a non-invasive imaging technique, can be used to reveal the location of re-oxygenation hence hypoxia in tumor.
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