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Abstract #5585

In Vivo Cardiac MR Elastography using a Gravitational Transducer

Ayse Sila Dokumaci1, Torben Schneider2, Myrianthi Hadjicharalambous1, Stefan-Heinz Hoelzl1, Jelizaveta Sudakova1, Daniel Hollands3, Ralph Sinkus1, and David Alexander Nordsletten1

1Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom, 2Philips Healthcare, Guildford, Surrey, United Kingdom, 3ITL Group, Ashford, Kent, United Kingdom

MR Elastography is valuable in evaluating biomechanical stiffness of tissues, which can exhibit marked changes in case of disease. However, the number of cardiac MRE studies remains limited due to challenges in measuring the dynamic muscle tissue using existing MRE sequences and hardware. Here, we aimed to acquire reliable cardiac MRE data by combining a gravitational transducer driven by a novel synchronising strategy with a single-shot SE-EPI-MRE sequence with flow and acceleration compensated motion encoding gradients to image the myocardium in different cardiac phases. Our method reveals higher myocardial stiffness, agreeing with results from biomechanical models/simulations, conflicting with current literature.

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