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Abstract #5588

Mechanical characterization of rat liver tissue in native, lysed and decellularized states by 0.5 T tabletop magnetic resonance elastography (MRE)

Angela Ariza de Schellenberger1,2, Hannah Everwien3, Nils Haep3, Igor Sauer3, Heiko Tzschätzsch1, Judith Bergs1, Jürgen Braun2, and Ingolf Sack1

1Elastography, Department of Radiology, Charité Universitätsmedizin, Berlin, Germany, 2Department of Medical Informatics, Charité Universitätsmedizin, Berlin, Germany, 3Chirurgische Klinik, Charité Universitätsmedizin, Berlin, Germany

Establishing the ideal 3D-matrix for organ regeneration is one of the big challenges in regenerative medicine. The mechanical properties of the extracellular matrix (ECM) are incompletely understood, partly due to the limited availability of volume-based mechanical test methods such as MRE. Therefore, we used a 0.5 T compact tabletop MRE system and measured the change of stiffness in rat livers due to decellularization and cell wall disruption by lysis. While the viscoelastic properties of intact liver tissue are determined by cells and can be described by a power law behavior, decellularized tissue has more solid-like properties following a Kelvin-Voigt-model behavior.

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