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Abstract #5592

Magnetic Resonance Elastography (MRE) Reveals Muscle Instability in Middle Aged Healthy Adults

Michael Perrins1,2, Michiel Simons2,3, Paul Kennedy4, Lisa Salisbury5, Colin Brown6, Timothy Walsh1,7, Edwin J.R. van Beek2, David Griffith1,7, and Neil Roberts2

1MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom, 2Edinburgh Imaging Facility, University of Edinburgh, Edinburgh, United Kingdom, 3Department of Clinical Surgery, University of Edinburgh, Edinburgh, United Kingdom, 4Department of Radiology, Icahn School of Medicine at Mount Sinai, Manhattan, NY, United States, 5Department of Physiotherapy, Queen Margaret University, Edinburgh, United Kingdom, 6The Mentholatum Company Ltd., East Kilbride, Glasgow, United Kingdom, 7Anaesthesia, Critical Care and Pain Medicine, University of Edinburgh, Edinburgh, United Kingdom

Age-related weakness and strength has been shown to have an anatomical basis, with stability of the knee being particularly prone to effects of ageing. Magnetic Resonance Elastography (MRE) was used to obtain muscle size and stiffness measurements in a ‘Younger’ and ‘Older’ group of participants. It was found that the Quadriceps muscle group were primarily impacted by age related atrophy, whilst also increasing in stiffness with age. Furthermore, the muscles along the medial side of the leg showed significantly lower muscle stiffness in ‘Older’ participants which we determined to be a biomarker for age-related anatomical instability.

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