Abstract #5601

Comparison of Magnetic Resonance Elastography (MRE) Inversion Reproducibility using MDEV and MREdge in the Brain for the Same Subjects at 1.5, 3 and 7 Tesla

Helen Marshall^1,2, Lucy Hiscox^1,3, Michael Perrins^1,2, Ingolf Sack⁴, Jürgen Braun⁴, Tom Meyer⁴, Tim Herrmann⁵, Johannes Bernarding⁵, Edwin J R van-Beek¹, Neil Roberts¹, and Eric Barnhill⁴

¹University of Edinburgh, Edinburgh, United Kingdom, ²Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom, ³Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom, ⁴Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁵Institute for Biometrics and Medical Informatics, Otto von Guericke University Magdeburg, Magdeburg, Germany

Magnetic Resonance Elastography (MRE) provides quantitative measures of the mechanical properties of biological tissues. As MRE becomes more widely used, it is important to assess different methods of data acquisition and analysis. In this study, a comparison was made between 3 field strengths using Multi-frequency duel Elasto Visco inversion (MDEV) and the new MREdge pipeline. Both inversions demonstrated significant differences in stiffness at each field strength, MDEV also displayed excellent correlation at 1.5, 3 and 7T. MDEV remains the preferred method of inversion with MREdge offering the prospect of an automatic pipeline which provides stiffness estimates for specific brain regions.

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