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Abstract #5601

Comparison of Magnetic Resonance Elastography (MRE) Inversion Reproducibility using MDEV and MREdge in the Brain for the Same Subjects at 1.5, 3 and 7 Tesla

Helen Marshall1,2, Lucy Hiscox1,3, Michael Perrins1,2, Ingolf Sack4, Jürgen Braun4, Tom Meyer4, Tim Herrmann5, Johannes Bernarding5, Edwin J R van-Beek1, Neil Roberts1, and Eric Barnhill4

1University of Edinburgh, Edinburgh, United Kingdom, 2Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom, 3Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom, 4Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 5Institute for Biometrics and Medical Informatics, Otto von Guericke University Magdeburg, Magdeburg, Germany

Magnetic Resonance Elastography (MRE) provides quantitative measures of the mechanical properties of biological tissues. As MRE becomes more widely used, it is important to assess different methods of data acquisition and analysis. In this study, a comparison was made between 3 field strengths using Multi-frequency duel Elasto Visco inversion (MDEV) and the new MREdge pipeline. Both inversions demonstrated significant differences in stiffness at each field strength, MDEV also displayed excellent correlation at 1.5, 3 and 7T. MDEV remains the preferred method of inversion with MREdge offering the prospect of an automatic pipeline which provides stiffness estimates for specific brain regions.

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