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Abstract #5631

Robust PD mapping using multi-contrast variable flip angle (VFA) data

Sara Lorio1, Tim Tierney2, Amy McDowell1, Owen Arthurs3, Antoine Lutti4, Nikolaus Weiskopf5, and David W. Carmichael1

1Great Ormond Street Institute of Child Health, UCL, London, United Kingdom, 2Wellcome Trust Centre for Neuroimaging, UCL, London, United Kingdom, 3Department of Radiology, Great Ormond Street Hospital, London, United Kingdom, 4LREN, University of Lausanne, Dept. of clinical neurosciences, CHUV, Lausanne, Switzerland, 5Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Proton density (PD) maps measure the amount of free water molecules in the tissue and can be used in a range of neurological disorders. However, current PD estimation methods in the brain rely on anatomical prior information which can be problematic in the case of severe tissue abnormalities. Here we propose a new approach for PD mapping based on a multi-contrast acquisition protocol, and a data-driven estimation method for inhomogeneity correction and map scaling. This approach can be applied on ex-vivo samples and in case of pronounced brain pathology because it does not require any anatomical nor tissue information.

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