The purpose of this study is to investigate the effect of switching from a linear to a macrocyclic GBCA on T1 signal enhancement in unenhanced T1-weighted brain images of pediatric patients. As in previous studies, significant signal intensity differences were observed in patients in the dentate nucleus and globus pallidus following serial administrations of a linear GBCA. In this study, a significant reduction in these signal intensities was also observed in these patients following several subsequent doses of a macrocyclic GBCA.
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