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Abstract #5654

Serial Quantitative Brain T1 Hyper-intensity Changes in Pediatric Patients Before and After Switching from Linear to Macrocyclic MRI Contrast Agents.

Amber Pokorney1, Ryan Robison1, and Jeffrey Miller1

1Radiology, Phoenix Children's Hospital, Phoenix, AZ, United States

The purpose of this study is to investigate the effect of switching from a linear to a macrocyclic GBCA on T1 signal enhancement in unenhanced T1-weighted brain images of pediatric patients. As in previous studies, significant signal intensity differences were observed in patients in the dentate nucleus and globus pallidus following serial administrations of a linear GBCA. In this study, a significant reduction in these signal intensities was also observed in these patients following several subsequent doses of a macrocyclic GBCA.

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