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Abstract #5660

The role of driver mutations in pediatric diffuse gliomas with histone H3 K27M mutation

Mariam Aboian1 and Soonmee Cha1

1University of California San Francisco, San Francisco, CA, United States

In this educational exhibit we will describe the imaging features of the new diagnostic entity based on 2016 CNS WHO classification – diffuse midline glioma with histone H3 K27M mutation. We will review the genetics of these tumors and will describe the common driver mutations that are detected. We will contrast the molecular signature of these tumors to hemispheric gliomas that have different imaging features and different outcomes.

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