In this educational poster, we emphasize the critical role that statistical parameter estimation plays in turning MRI relaxometry into an accurate and precise qMRI modality. In this longstanding goal, most of the efforts have been made on deriving more accurate physical models, but, to the authors’ knowledge, the importance of using modern statistical parameter estimation methods has been overlooked. Here, we present "the do's and the don’ts" of statistical parameter estimation for quantitative MRI relaxometry, illustrating all the concepts with real-case scenarios.
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