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Abstract #5667

Preclinical MR spectroscopy for studies of in vivo myocardial energy metabolism in heart failure

Desiree Abdurrachim1, Adrianus J Bakermans2, Klaas Nicolay3, Philip Teck Hock Lee1, and Jeanine J Prompers3,4

1Singapore Bioimaging Consortium, Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore, 2Department of Radiology, Academic Medical Center, Amsterdam, Netherlands, 3Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 4Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Changes in myocardial energy metabolism have been thought to contribute to the development of heart failure. Here, we will review methods and applications of cardiac 1H MRS, 31P MRS, and hyperpolarized 13C MRS techniques in probing myocardial energy metabolism in vivo in small animal models of heart failure.

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