Abstract #0015

Oxygen-enhanced UTE MRI for Quantification of Dynamic Lung Function

Wei Zha¹, Kevin M Johnson^1,2, Robert V Cadman¹, Scott K Nagle^1,2,3, and Sean B Fain^1,2,4

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Three-dimensional dynamic imaging using free-breathing oxygen-enhanced (OE) ultrashort echo time (UTE) MRI can measure change of partial pressure of oxygen (ΔPO₂) and wash-in/out time constants. Nine healthy subjects underwent the dynamic OE MRI protocol at 1.5T. A subset of 4 subjects underwent repeated exams and 2 of these 4 underwent the same protocol at 3.0T on the same day. The inter-exam variations at 1.5T suggest good quantitative measurements of lung function and wash-in/out dynamics with variations observed in ΔPO_2max. The parametric maps imply comparable wash-in/out time constants and normal ventilation measured at 1.5T vs. 3.0T.

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