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Abstract #0035

Changes in functional brain connectivity associated with the development of executive functions during early childhood

Giang-Chau Ngo1,2, Muriel M. K. Bruchhage1,2, John L. Rogers1,2, Joshua Beck1,2, Viren D'Sa1,2, and Sean C.L. Deoni1,2,3

1Warren Alpert Medical School, Department of Pediatrics, Brown University, Providence, RI, United States, 2Women and Infants Hospital of Rhode Island, Providence, RI, United States, 3MNCHD&T, Bill & Melinda Gates Foundation, Seattle, WA, United States

Task-based functional MRI (fMRI) has been commonly used to study executive functions but may be difficult to implement for children younger than 5-year-old. In this work, resting sate fMRI is combined with in-house tablet-based tasks which evaluate reaction and inhibition control in children from 2 to 5 years of age. The aim is to determine differences in brain connectivity related to the children’s performance of these two tasks. Preliminary results demonstrated the importance of the language, visual and attention networks during the reaction task and asymmetrical changes in frontal parietal and sensorimotor network connectivity associated with the development of inhibition control.

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