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Abstract #0052

Neurovascular coupling in task and resting state using simultaneous calcium fiber photometry and fMRI in rats

Chuanjun Tong1, Jiankun Dai2, Yanqiu Feng1, and Zhifeng Liang2

1Institution of Medical Information, Sourthern Medical University, Guangzhou, China, 2Institution of Neuroscience, Shanghai, China

Neurovascular coupling is the foundation of functional brain imaging. We developed a dual site, dual color simultaneous GCaMP6-based fiber photometry and fMRI recording system in rats, to simultaneously record calcium and BOLD signals. Our results revealed the strong couplings in the task condition, and much weaker but still significant coupling in the resting state. We also showed that in the resting state such coupling was susceptible to different preprocessing steps. Our results provided a novel perspective on neurovascular coupling in task and resting state conditions.

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