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Abstract #0054

Exploration of the spatial and temporal characteristics of sensorimotor neural activity in the preterm human brain with simultaneous EEG-fMRI

Tanya Poppe1, Kimberly Whitehead2, Sofia Dall'Orso3, Camilla O'Keefe1, Jakki Brandon1, Katy Vecchiato1, Rui Pedro A G Teixeira1, Felipe Godinez1, Anthony N Price1, A David Edwards1, Lorenzo Fabrizi1, and Tomoki Arichi1,3

1Centre for the Developing Brain, Kings College London, London, United Kingdom, 2Department of Neuroscience Physiology and Pharmacology, University College London, London, United Kingdom, 3Department of Bioengineering, Imperial College London, London, United Kingdom

In the developing animal brain, different patterns of neural activity have distinct roles in the establishment of brain networks at different scales. Although studies suggest that the human preterm period is a crucial time for establishing brain connectivity, the role of different frequencies of neural activity has not been studied. We therefore used simultaneous EEG-fMRI and a robotic somatosensory stimulus to study the temporal and spatial characteristics of evoked neural activity in a group of preterm infants. Specific types of neural activity were associated with different BOLD responses, suggesting that these methods offer new insights into developing brain activity.

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