Abstract #0094

Sensitivity Study of 4D flow Left Ventricular Hemodynamics Parameters in Healthy Volunteers and Dilated Cardiomyopathy Patients

Pamela Alejandra Franco^1,2,3, Julio Sotelo^1,2,3, Bram Ruijsink⁴, David Nordsletten⁴, Eric Kerfoot⁴, Joaquín Mura^1,2, Cristian Tejos^1,2,3, Daniel Hurtado^1,5,6, and Sergio Uribe^1,2,6,7

¹Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile, ²Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, ³Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁴Biomedical Engineering, King's College London, London, United Kingdom, ⁵Structural and Geotechnical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁶Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁷Radiology Department, Pontificia Universidad Católica de Chile, Santiago, Chile

Segmentation of the Left Ventricle (LV) from MRI and 4D flow datasets is an essential step for quantifying clinical indices and hemodynamic parameters. Automatic methods for heart segmentation are generally validated using cardiac volumetric and global ejection fraction. However, little is known about the changes of hemodynamic parameters when subjected to different segmentations. In this study, we present a sensitivity assessment of left intraventricular hemodynamic parameters in healthy volunteers and Dilated Cardiomyopathy (DCM) patients using a finite element quantification approach using 4D flow MRI data, when subjected to changes of LV segmentations.

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