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Abstract #0136

Cortical bone quantifications using ultrashort echo time MR imaging (UTE-MRI) correlate well with histomorphometric assessment of bone microstructure

Saeed Jerban1, Yajun Ma1, Jonathan H Wong2, Amin Nazaran1, Adam Searleman1, Lidi Wan1, Judith Williams2, Eric Y Chang1,2, and Jiang Du1

1Radiology, University of california, San Diego, San Diego, CA, United States, 2Radiology Service, VA San Diego Healthcare System, San Diego, CA, United States

Ultrashort echo time magnetic resonance imaging (UTE-MRI) has been used to assess cortical bone porosity, as validated routinely with high resolution micro computed tomography (μCT). This study investigated the correlations between UTE-MRI-based quantifications and histomorphometric measures, as well as between UTE-MRI-based quantifications and μCT results. MRI properties showed strong correlations with both histomorphometric and μCT-based porosities. Only UTE-MRI could assess small pore (<40 μm) variations with moderate correlations. Major porosity changes were from large pores in studied specimens; therefore, μCT employment is likely adequate to validate UTE-MRI biomarkers. However, UTE-MRI techniques can assess pores below the detectable range by μCT, porosities which might contribute differently to bone mechanics.

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