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Abstract #0158

Quantification and Repeatability of the Collagen Signal Fraction in the Healthy Liver Using Ultrashort Echo Time (UTE) MRI

Adrienne G. Siu1, Ferenc E. Mózes1, Luca Biasiolli1, and Matthew D. Robson1

1Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

Liver injury can lead to fibrosis, i.e. an accumulation of collagen. Fibrosis is clinically assessed via biopsy. Due to the health risks and unrepresentative sampling associated with biopsy, a non-invasive method of quantifying collagen would be beneficial. Here, an ultrashort echo time (UTE) pulse sequence was employed to quantify the collagen signal fraction in 10 subjects with healthy livers in a test-retest study at 3 T. The collagen signal fraction was repeatable, with a mean of 14 ± 3 %.

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