Abstract #0166

On the intrahemispheric connectivity of the monkey: a diffusion tractography and tract tracing analysis

Gabriel Girard^1,2, Roberto Caminiti^3,4, Alexandra Battaglia-Mayer³, Etienne St-Onge⁵, Karen S. Ambrosen^6,7, Simon F. Eskildsen⁸, Kristine Krug⁹, Tim B. Dyrby^7,10, Maxime Descoteaux⁵, Giorgio Innocenti^11,12, and Jean-Philippe Thiran^1,2

¹Radiology Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland, ²Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Department of Physiology and Pharmacology, University of Rome SAPIENZA, Rome, Italy, ⁴Department of Anatomy, Histology, Forensic Medicine, and Orthopedics, University of Rome SAPIENZA, Rome, Italy, ⁵Sherbrooke Connectivity Imaging Lab, Computer Science Department, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁶Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, ⁷Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, ⁸Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁹Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, ¹⁰Department of Applied Mathematics an Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, ¹¹Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, ¹²Brain and Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

In this work, we compare diffusion tractography with neuronal retrograde tract tracing of the frontal, cingulate and parietal areas of the monkey. We analyze the agreements between the tractography and the tracing for connected and not connected regions. We report an accuracy of 0.71 across all pairs of regions, with twice the number of true positive than false positive connections. Some regions show accuracy higher than 0.80, while other regions show accuracy lower than 0.6. A further analysis of the location of false positive and false negative connections will help understand the limitations and improve diffusion tractography algorithms.

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