Meeting Banner
Abstract #0173

The neurometabolic correlates of motor performance across the adult lifespan: a study on the effects of age

Akila Weerasekera1, Oron Levin1, Brad King1, Kirstin Heise1, Diana Sima2, Sima Chalavi3, Celine Maes3, Lize Hermans3, Ronald Peeters4, Koen Cuypers3, Sabine Van Huffel3, Dante Mantini3, Uwe Himmelreich3, and Stephan Swinnen3

1University of Leuven, Leuven, Belgium, 2icometrix, Leuven, Belgium, 3University of Leuven, leuven, Belgium, 4University Hospital Leuven, Leuven, Belgium

Aging is associated with alterations in neurochemistry of the brain, which can be assessed by MR spectroscopy. However, it’s unclear which metabolites are critical for function of the motor network. We explored whether changes in the neurometabolites of the aging brain account for motor-declines in bimanual coordination. We focused on neurochemistry of motor-occipital cortices as both regions are nodes of sensorimotor network underlying bimanual control. Myo-inositol was relevant for predicting Perdue test, which examine manual dexterity and general bimanual skills whereas N-acetylaspartate was associated with bimanual coordination task. Findings indicate NAA and mI could serve as biomarkers for integrity of motor network.

This abstract and the presentation materials are available to members only; a login is required.

Join Here