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Abstract #0178

In vivo cystathionine detection in gliomas by edited 1H magnetic resonance spectroscopy

Francesca Branzoli1,2, Dinesh K Deelchand3, Anna Luisa Di Stefano4,5, Marc Sanson2,4,6, Stéphane Lehéricy1,2, and Małgorzata Marjańska3

1Centre de NeuroImagerie de Recherche (CENIR), Institut du Cerveau et de la Moelle épinère (ICM), Paris, France, 2Sorbonne Université, UMR S 1127, Inserm U 1127, CNRS UMR 7225, Paris, France, 3Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 4AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Neurologie 2, Paris, France, 5Department of Neurology, Foch Hospital, Suresnes, Paris, France, 6Onconeurotek tumor bank, Institut du Cerveau et de la Moelle épinère (ICM), Paris, France

This study reports the first measurement of cystathionine in vivo. Cystathionine was measured using the edited magnetic resonance spectroscopy (MRS). The identification of cystathionine was confirmed by comparing in vivo spectra acquired in gliomas with the cystathionine spectrum measured in a phantom at physiological pH and temperature and with a simulated spectrum generated using accurate chemical shifts and J-coupling constants. The noninvasive detection of cystathionine by MRS may represent a new in vivo marker of glioma subtypes which will benefit diagnosis and treatment of patients with gliomas.

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