Microstructural abnormalities in the white matter are important in the pathophysiology of schizophrenia. Unlike to unspecific nature of water, MRS can probe the brain's intracellular microenvironment through the measurement of transverse relaxation and diffusion of neurometabolites and even providecell-specific information. In this study, we worked with first episode schizophreniapatients so as to obviate the effects of medications and toxic effects of chronic psychosis. A combination of the T2-MRS and DTS techniques were applied in a longitudinal study. NAA T2 and ADC showed more sensitive changes compared to water at the early stage of disease.
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