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Abstract #0180

Metabolite relaxation and diffusion abnormalities in the white matter of first-episode schizophrenia: a longitudinal study

Xi Chen1,2, Xiaoying Fan1, Talia Cohen1, Margaret Gardner1, Fei Du1,2, and Dost Ongur1,2

1McLean Hospital, Belmont, MA, United States, 2Harvard Medical School, Boston, MA, United States

Microstructural abnormalities in the white matter are important in the pathophysiology of schizophrenia. Unlike to unspecific nature of water, MRS can probe the brain's intracellular microenvironment through the measurement of transverse relaxation and diffusion of neurometabolites and even providecell-specific information. In this study, we worked with first episode schizophreniapatients so as to obviate the effects of medications and toxic effects of chronic psychosis. A combination of the T2-MRS and DTS techniques were applied in a longitudinal study. NAA T2 and ADC showed more sensitive changes compared to water at the early stage of disease.

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