Abstract #0196

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy

Xin Shen¹, Natalie Voets², Sarah Larkin², Nick de Pennington², Puneet Plaha³, Richard Stacey³, James Mccullagh², Christopher Schofield², Stuart Clare², Peter Jezzard², Tom Cadoux-Hudson³, Olaf Ansorge², and Uzay Emir^1,2,4

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ²University of Oxford, Oxford, United Kingdom, ³Oxford University Hospitals NHS Trust, Oxford, United Kingdom, ⁴School of Health Sciences, Purdue University, West Lafayette, IN, United States

The oncogenes that are expressed in gliomas reprogram particular pathways of glucose, amino acid, and fatty acid metabolism. Mutations in the isocitrate dehydrogenase genes (IDH1/2) in diffuse gliomas are associated with abnormally high 2-hydroxyglutarate (2-HG) levels. Non-invasive measurement of 2-HG via in vivo ¹H magnetic resonance spectroscopy (MRS) can be used to differentiate mutant cytosolic IDH1 from mitochondrial IDH2 in gliomas.

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