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Abstract #0196

A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy

Xin Shen1, Natalie Voets2, Sarah Larkin2, Nick de Pennington2, Puneet Plaha3, Richard Stacey3, James Mccullagh2, Christopher Schofield2, Stuart Clare2, Peter Jezzard2, Tom Cadoux-Hudson3, Olaf Ansorge2, and Uzay Emir1,2,4

1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2University of Oxford, Oxford, United Kingdom, 3Oxford University Hospitals NHS Trust, Oxford, United Kingdom, 4School of Health Sciences, Purdue University, West Lafayette, IN, United States

The oncogenes that are expressed in gliomas reprogram particular pathways of glucose, amino acid, and fatty acid metabolism. Mutations in the isocitrate dehydrogenase genes (IDH1/2) in diffuse gliomas are associated with abnormally high 2-hydroxyglutarate (2-HG) levels. Non-invasive measurement of 2-HG via in vivo 1H magnetic resonance spectroscopy (MRS) can be used to differentiate mutant cytosolic IDH1 from mitochondrial IDH2 in gliomas.

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