Abstract #0201

Androgen Independence Leads to Altered Metabolism in Prostate Cancer Cell and Murine Models

Jinny Sun¹, Justin Delos Santos¹, Robert Bok¹, Romelyn Delos Santos¹, Mark Van Criekinge¹, Daniel B Vigneron¹, Renuka Sriram¹, and John Kurhanewicz¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

This study demonstrated significant increases in flux through glycolysis, oxidative metabolism, and glutaminolysis associated with androgen independence using patient-derived cell lines and a treatment-driven murine model. This data supports using a combination of hyperpolarized [1-¹³C]pyruvate, [2-¹³C]pyruvate and [5-¹³C]glutamine to noninvasively discriminate between androgen-dependent and androgen-independent prostate cancer in future patient studies using hyperpolarized 13C MRI.

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