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Abstract #0201

Androgen Independence Leads to Altered Metabolism in Prostate Cancer Cell and Murine Models

Jinny Sun1, Justin Delos Santos1, Robert Bok1, Romelyn Delos Santos1, Mark Van Criekinge1, Daniel B Vigneron1, Renuka Sriram1, and John Kurhanewicz1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

This study demonstrated significant increases in flux through glycolysis, oxidative metabolism, and glutaminolysis associated with androgen independence using patient-derived cell lines and a treatment-driven murine model. This data supports using a combination of hyperpolarized [1-13C]pyruvate, [2-13C]pyruvate and [5-13C]glutamine to noninvasively discriminate between androgen-dependent and androgen-independent prostate cancer in future patient studies using hyperpolarized 13C MRI.

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