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Abstract #0208

Baseline Striatal Dopamine Binding Potential Predicts Functional Connectivity to Ventral Tegmental Area in Control but not in MDD: A Simultaneous [11C] Raclopride PET-fMRI Study

Xue Zhang1,2, Fuyixue Wang3,4, J. Paul Hamilton5, Jingyuan E. Chen4,6, Ian H. Gotlib7, Mehdi Khalighi8, and Gary H. Glover2

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 2Radiological Sciences Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, United States, 3Harvard-MIT Health Sciences and Technology, MIT, Boston, MA, United States, 4A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 5Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden, 6Department of Radiology, Harvard Medical School, Boston, MA, United States, 7Department of Psychology, Stanford University, Palo Alto, CA, United States, 8Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

Our previous work has indicated a significant connection between dopamine release/binding and fMRI activation during reward processing in healthy controls (CTL), but not in major depressive disorder (MDD). It motivates us to explore whether there is a similar disrupting effect in the coupling of resting-state fMRI and baseline dopamine binding potential in MDD. By conducting a simultaneous [11C] Raclopride PET and fMRI study, we obtained significant correlations between striatal dopamine binding potential and VTA-striatum functional connectivity in CTL, but not in MDD, indicating that the decoupling of dopaminergic system and striatum may play a vital role in the pathophysiology of MDD.

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