Abstract #0208

Baseline Striatal Dopamine Binding Potential Predicts Functional Connectivity to Ventral Tegmental Area in Control but not in MDD: A Simultaneous [11C] Raclopride PET-fMRI Study

Xue Zhang^1,2, Fuyixue Wang^3,4, J. Paul Hamilton⁵, Jingyuan E. Chen^4,6, Ian H. Gotlib⁷, Mehdi Khalighi⁸, and Gary H. Glover²

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ²Radiological Sciences Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, United States, ³Harvard-MIT Health Sciences and Technology, MIT, Boston, MA, United States, ⁴A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁵Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden, ⁶Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁷Department of Psychology, Stanford University, Palo Alto, CA, United States, ⁸Applied Science Lab, GE Healthcare, Menlo Park, CA, United States

Our previous work has indicated a significant connection between dopamine release/binding and fMRI activation during reward processing in healthy controls (CTL), but not in major depressive disorder (MDD). It motivates us to explore whether there is a similar disrupting effect in the coupling of resting-state fMRI and baseline dopamine binding potential in MDD. By conducting a simultaneous [¹¹C] Raclopride PET and fMRI study, we obtained significant correlations between striatal dopamine binding potential and VTA-striatum functional connectivity in CTL, but not in MDD, indicating that the decoupling of dopaminergic system and striatum may play a vital role in the pathophysiology of MDD.

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