Abstract #0210

Simultaneous Measurement of functional MRI and MRS by Fast Non-water Suppressed Keyhole MR Spectroscopy Imaging

Xin Shen¹, Pingyu Xia², Masoumeh Dehghani ‎Moghadam³, Jamie Near^3,4, Xiaopeng Zhou², Mark Chiew⁵, Ulrike Dydak^2,6, and Uzay Emir^1,2

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ²School of Health Sciences, Purdue University, West Lafayette, IN, United States, ³Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁴Centre d'Imagerie Cérébrale, Douglas Mental Health University Institute, Montreal, QC, Canada, ⁵Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ⁶Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

The non-water suppressed magnetic resonance spectroscopic imaging (MRSI) sequence with concentric k-space trajectory was proposed to measure functional MRI and MRSI signals simultaneously. A right-hand finger-tapping task was performed at 3T MRI scanner to test the simultaneous hemodynamic and neurochemical measurements at human primary motor cortex. The results showed a significant overlap between T2* and metabolite (glutamate) changes.

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