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Abstract #0210

Simultaneous Measurement of functional MRI and MRS by Fast Non-water Suppressed Keyhole MR Spectroscopy Imaging

Xin Shen1, Pingyu Xia2, Masoumeh Dehghani ‎Moghadam3, Jamie Near3,4, Xiaopeng Zhou2, Mark Chiew5, Ulrike Dydak2,6, and Uzay Emir1,2

1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2School of Health Sciences, Purdue University, West Lafayette, IN, United States, 3Department of Psychiatry, McGill University, Montreal, QC, Canada, 4Centre d'Imagerie Cérébrale, Douglas Mental Health University Institute, Montreal, QC, Canada, 5Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 6Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

The non-water suppressed magnetic resonance spectroscopic imaging (MRSI) sequence with concentric k-space trajectory was proposed to measure functional MRI and MRSI signals simultaneously. A right-hand finger-tapping task was performed at 3T MRI scanner to test the simultaneous hemodynamic and neurochemical measurements at human primary motor cortex. The results showed a significant overlap between T2* and metabolite (glutamate) changes.

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