Abstract #0227

Diffusion acquisition methods for unfixed ex vivo neonatal brain scan at 7T: sequence optimisation and preliminary experiments

Wenchuan Wu¹, Jerome Sallet^1,2, Rogier B Mars¹, Benjamin C Tendler¹, Matteo Bastiani^1,3, Sebastian W Rieger¹, Daniel Papp¹, Jacques-Donald Tournier^4,5, Joseph V Hajnal^4,5, and Karla L Miller¹

¹Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ²Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom, ³Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁴Centre for the Developing Brain, King's College London, London, United Kingdom, ⁵Biomedical Engineering Department, King's College London, London, United Kingdom

In this work we present preliminary investigations into the use of diffusion-weighted steady state free procession (DW-SSFP) sequences and conventional diffusion-weighted spin-echo (DW-SE) sequences for unfixed neonate brains. We conduct an exploratory experiment to demonstrate the feasibility of existing dMRI methods on an unfixed porcine brain. We then propose a framework to match DW-SE and DW-SSFP contrast in a way that predicts optimal performance of each, in order to compare between methods.

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