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Abstract #0227

Diffusion acquisition methods for unfixed ex vivo neonatal brain scan at 7T: sequence optimisation and preliminary experiments

Wenchuan Wu1, Jerome Sallet1,2, Rogier B Mars1, Benjamin C Tendler1, Matteo Bastiani1,3, Sebastian W Rieger1, Daniel Papp1, Jacques-Donald Tournier4,5, Joseph V Hajnal4,5, and Karla L Miller1

1Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 2Department of Experimental Psychology, University of Oxford, Oxford, United Kingdom, 3Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 4Centre for the Developing Brain, King's College London, London, United Kingdom, 5Biomedical Engineering Department, King's College London, London, United Kingdom

In this work we present preliminary investigations into the use of diffusion-weighted steady state free procession (DW-SSFP) sequences and conventional diffusion-weighted spin-echo (DW-SE) sequences for unfixed neonate brains. We conduct an exploratory experiment to demonstrate the feasibility of existing dMRI methods on an unfixed porcine brain. We then propose a framework to match DW-SE and DW-SSFP contrast in a way that predicts optimal performance of each, in order to compare between methods.

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