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Abstract #0248

Reduced Regional Cerebral Venous Oxygen Saturation is a Risk Factor for Cognitive Impairment in Hemodialysis Patients: A Susceptibility-weighted Image Mapping Study

Chao Chai1, Huiying Wang1, Jinping Li2, Jinxia Zhu3, Xianchang Zhang3, E. Mark Haacke4, Shuang Xia1, and Wen Shen1

1Department of Radiology, Tianjin First Central Hospital, Tianjin, China, 2Deparment of Hemodialysis, Tianjin First Central Hospital, Tianjin, China, 3MR Collaboration, Siemens Healthcare Ltd., Beijing, China, 4Department of Radiology, Wayne State University, Detroit, MI, United States

The purpose of this study was to noninvasively evaluate the changes of regional cerebral venous oxygen saturation (rSvO2) in hemodialysis patients using quantitative susceptibility-weighted image mapping (SWIM) and then to investigate the relationship between rSvO2, clinical risk factors, and neuropsychological testing results. The results suggest that cerebral rSvO2 is reduced in hemodialysis patients and that this reduction may correlate with neurocognitive dysfunction. Hematocrit, iron, glucose, and pre- and post-dialysis DBP were independent risk factors for reduced cerebral rSvO2.

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