Expression of telomerase reverse transcriptase (TERT) is a fundamental hallmark of cancer. Identification of imaging biomarkers of TERT expression will facilitate non-invasive assessment of tumor burden and response to therapy. Our studies in glioma indicate that TERT expression leads to increased redox capacity characterized by elevated 1H-MRS-detectable glutathione and NADPH. Concomitantly, TERT increases 13C-MRS-detectable flux of glucose through the pentose phosphate pathway, which provides NADPH. Importantly, hyperpolarized [U-2H, U-13C]-glucose and hyperpolarized [1-13C]-dehydroascorbic acid can image these alterations in glucose and redox metabolism. Our study identifies potential non-invasive translational metabolic imaging probes of TERT expression in glioma and possibly other cancers.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords