Abstract #0255

Hyperpolarized C-13 bSSFP Imaging of the Human Brain

Eugene Milshteyn^1,2, Cornelius von Morze³, Jeremy W. Gordon³, Galen D. Reed⁴, Adam Autry³, Hsin-Yu Chen³, Daniele Mammoli³, Robert A. Bok³, James B. Slater³, Mark Van Criekinge³, Lucas Carvajal³, Duan Xu³, Peder E. Z. Larson³, Sarah J. Nelson³, John Kurhanewicz³, and Daniel B. Vigneron³

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ⁴GE Healthcare, Dallas, TX, United States

Current early phase clinical trials of hyperpolarized C-13 imaging of the brain, prostate, and liver have demonstrated the exceptional ability to rapidly visualize metabolism of pyruvate at high spatiotemporal resolutions. Prior human studies have used MRSI, EPSI, EPI, and spiral MRI and MRSI. In this study, we investigated for the first time the bSSFP sequence with its high SNR efficiency for human hyperpolarized C-13 imaging of pyruvate and lactate. This research showed the ability to acquire dynamic 1-1.5cm isotropic bSSFP images of the human brain in a clinical setting.

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