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Abstract #0257

Hyperpolarized [1-13C]pyruvate MRS in a large animal model of partial renal obstruction supports clinical use in patients

Esben Søvsø Szocska Hansen1, Uffe Kjærgaard1, Rasmus Stilling Tougaard1,2, Rolf F. Schulte3, Hans Stødkilde-Jørgensen1, and Christoffer Laustsen1

1MR Research Centre, Aarhus University, Aarhus N, Denmark, 2Department of Cardiology, Aarhus University Hospital, Skejby, Denmark, 3GE Healthcare, Munich, Germany

Hyperpolarized [1-13C]pyruvate was used in this study to explorer the capability of detecting ischemic injury in the kidneys and to present the heterogeneity from the different kidney compartments. This was done using Michaelis–Menten kinetics by obtaining data in the an saturation recovery setup. Ischemic injuries was observed and in close correlation to standard perfusion MRI. The results from this study shows promise for the human introduction of this method.

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