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Abstract #0266

Spatial profiling of endogenous cellular iron MRI contrast by machine vision classifies macrophage infiltration in breast cancer models of metabolic- and immune-therapy

Avigdor Leftin1,2 and Jason Koutcher1

1Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Radiology, Stony Brook Medicine, Stony Brook, NY, United States

Tumor macrophage response to therapy is conventionally detected with iron nanoparticle-enhanced MRI. However, endogenous cellular iron detection methods exist that can bypass caveats intrinsic to contrast agent use. We demonstrate that contrast-agent free multi-gradient echo R2* relaxometry iron MRI and machine vision analysis approaches can map tumor macrophage iron deposits and detect cellular response to metabolic and immunotherapy in preclinical models of breast cancer. Feasibility of endogenous macrophage imaging is shown, and the value of the cellular MRI biomarker is demonstrated as a function of treatment and tumor model.

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