We aimed to re-evaluate DWI of pre-surgical MRI as a clue to diagnose pCR or non-pCR. DCE-MRI including kinetic information were also evaluated for comparison. DWI-based evaluation of residual disease in pre-surgical MRI demonstrate excellent diagnostic performance. On the other hand, residual disease is difficult to evaluate based on kinetic information. DWI-based evaluation of residual disease is a useful approach in pre-surgical evaluation of breast cancer following neoadjuvant systemic treatment.