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Abstract #0291

Cerebral hypometabolism measured with intravascular T2-prepared tissue relaxation with inversion recovery (T2-TRIR) and pCASL in adults with sickle cell disease

Lena Vaclavu1,2, Esben Thade Petersen3, Henri JMM Mutsaerts1, Jan Petr4, Charles BLM Majoie1, John C Wood5, Ed T VanBavel6, Bart J Biemond7, and Aart J Nederveen1

1Department of Radiology & Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 2C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark, 4Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany, 5Department of Cardiology and Radiology, Children’s Hospital of Los Angeles, Los Angeles, CA, United States, 6Department of Biomedical Engineering & Physics, Amsterdam UMC, Amsterdam, Netherlands, 7Department of Hematology, Amsterdam UMC, Amsterdam, Netherlands

Cerebral metabolic rate of oxygen (CMRO2) quantifies the amount of oxygen consumed by the brain, and relies on continuous delivery of nutrients and oxygen via cerebral blood flow (CBF). In sickle cell disease (SCD), CBF is elevated to compensate for chronic anaemia. This study investigates CMRO2 in adults with SCD using T2-prepared tissue relaxation with inversion recovery (T2-TRIR). CBF increased after acetazolamide-induced vasodilation in both groups but CMRO2 reduced even further in SCD patients while it remained stable in controls. Our results suggest that cerebral shunting is exacerbated by high flow conditions.

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