Meeting Banner
Abstract #0293

White matter microstructural alterations in chronic, episodic, and aura migraine

Benjamin Ades-Aron1, Sait Ashina2, Bettina Conti1, Yvonne W Lui1, Mia Minen3, Dmitry S Novikov1, Timothy Shepherd1, and Els Fieremans1

1Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, NY, United States, 2Neurology, Beth Israel Deaconess Medical Center, Brookline, MA, United States, 3Neurology, New York University School of Medicine, New York, NY, United States

Migraine is associated with increased risk for stroke and white matter abnormalities, though the exact nervous tissue pathology remains poorly understood. This study used diffusion kurtosis imaging, a clinically feasible extension of diffusion tensor imaging, to compare white matter microstructural changes in migraineurs to healthy controls, and between their different subtypes: chronic, episodic, with and without aura. Using a voxel-wise statistical approach, we found that axial and radial kurtosis were significantly altered depending on migraine subtype. While radial kurtosis is significantly reduced in all migraine patients compared to controls, axial kurtosis is increased in episodic migraines with and without aura, suggesting different underlying pathology.

This abstract and the presentation materials are available to members only; a login is required.

Join Here