Migraine is associated with increased risk for stroke and white matter abnormalities, though the exact nervous tissue pathology remains poorly understood. This study used diffusion kurtosis imaging, a clinically feasible extension of diffusion tensor imaging, to compare white matter microstructural changes in migraineurs to healthy controls, and between their different subtypes: chronic, episodic, with and without aura. Using a voxel-wise statistical approach, we found that axial and radial kurtosis were significantly altered depending on migraine subtype. While radial kurtosis is significantly reduced in all migraine patients compared to controls, axial kurtosis is increased in episodic migraines with and without aura, suggesting different underlying pathology.
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