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Abstract #0304

Column-specific microstructural changes in patients with non-myelopathic degenerative compression of the cervical spinal cord revealed by diffusion MRI

Jan Valošek1,2, René Labounek1,3, Tomáš Horák4,5, Alena Svátková4,6, Petr Kudlička4, Pavel Hok1, Jan Kočica4,5, Christophe Lenglet7, Petr Hluštík1, Josef Bednařík4,5, and Petr Bednařík4,8

1Department of Neurology, University Hospital Olomouc, Olomouc, Czech Republic, 2Department of Biomedical Engineering, University Hospital Olomouc, Olomouc, Czech Republic, 3Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, 4Central European Institute of Technology, Masaryk University, Brno, Czech Republic, 5Department of Neurology, University Hospital Brno, Brno, Czech Republic, 6Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, 7Center for Magnetic Resonance Research, Minneapolis, MN, United States, 8High Field MR Centre, Medical University of Vienna, Vienna, Austria

While delineation of microstructural changes in white matter (WM) columns of cervical spinal cord (CSC) in patients with non-myelopathic degenerative CSC compression (NMDCSCC) remains a challenge for most current MRI techniques, High Angular Resolution Diffusion Imaging (HARDI) protocols promise to overcome this issue. Thus, our group utilized novel HARDI-ZOOMit protocol to extract metrics from diffusion tensor and ball-and-stick models in three major CSC columns. HARDI-ZOOMit protocol was able to detect column-specific significant differences between healthy controls and patients with NMDCSCC with more complex abnormalities in ventral CSC columns in C3-C6 levels.

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