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Abstract #0312

T2-gSlider: rapid high resolution T2 mapping with generalized SLIce Dithered Enhanced Resolution and model-based reconstruction

Xiaozhi Cao1, Congyu Liao2,3, Siddharth Srinivasan Iyer3,4, Hongjian He1, Kawin Setsompop2,3, Jianhui Zhong1,5, and Berkin Bilgic2,3

1Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China, 2Department of Radiology, Harvard Medical School, Charlestown, MA, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 4Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 5Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

To obtain rapid high isotropic resolution whole-brain T2 maps, a T2 generalized Slice-dithered enhanced resolution (T2-gSlider) acquisition/reconstruction framework is proposed. An accelerated RF-encoded multi-slab, multi-shot SE-EPI acquisition with variable TEs was developed to obtain high SNR acquisitions with reduced TR. A structured low-rank constraint was applied to reconstruct highly undersampled multi-shot data and achieve robust reconstruction for each slab. A Bloch simulated subspace shuffling model was utilized for T2 quantification and incorporated into gSlider reconstruction to further accelerate the acquisition. The proposed framework is demonstrated to enable whole-brain 1mm isotropic T2 mapping in ~40 seconds.

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