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Abstract #0315

Whole-brain 3D multi-parametric quantitative extraction at 7T using parallel transmission Universal Pulses

Lisa Leroi1, Vincent Gras1, Ludovic de Rochefort2, Mathieu D. Santin3,4, Romain Valabrègue3,4, Franck Mauconduit5, Denis Le Bihan1, Nicolas Boulant1, and Alexandre Vignaud1

1CEA - Neurospin, Gif-sur-Yvette, France, 2CRMBM/UMR 7339 CNRS, Aix Marseille Université, Marseille, France, 3CENIR, ICM, Paris, France, 4Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France, 5Siemens Healthineers, Saint-Denis, France

Performing simultaneous quantitative MRI at ultra-high field is challenging, as B0 and B1 heterogeneities, and Specific Absorption Rate increase with field strength. In this work, Quantitative Imaging using Configuration States is successfully applied in vivo at 7T using calibration-free parallel transmission Universal Pulses to retrieve 3D whole-brain M0, flip angle, T1 and T2 maps in a clinically-relevant time. The method relies on the acquisition of multiple contrasts with spoiled SSFP sequence by varying flip angle and radiofrequency spoiling in a limited and optimized number of sets. Quantification of the physical parameters was then performed by fitting acquired data to the Bloch-Torrey equation.

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