Abstract #0318

Separating intra- and extra-axonal susceptibility effects using a Diffusion-Filtered Asymmetric Spin Echo (D-FASE) sequence

Elena Kleban¹, Chantal M W Tax¹, Umesh S Rudrapatna¹, Derek K Jones^1,2, and Richard Bowtell³

¹Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff, UK, Cardiff, United Kingdom, ²School of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia, ³Sir Peter Mansfield Imaging Centre, School of Physiscs and Astronomy, University of Nottingham, Nottingham, UK, Nottingham, United Kingdom

The investigation of brain white matter is a key area of application of MRI, with much effort focused on using MR techniques to quantify tissue microstructure. Here, we bring together two complementary approaches that are commonly used to probe tissue microstructure (signal dephasing due to: (i) diffusion and (ii) microscopic susceptibility effects) using a novel Diffusion-Filtered Asymmetric Spin Echo (D-FASE) technique. Using D-FASE we can separately assess the evolution of the intra- and extra-axonal signals under the action of susceptibility effects, revealing differences in the behaviour in fibres that are parallel and perpendicular to B₀.

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