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Abstract #0331

Characteristic Normal Ageing Patterns of White Matter Tracts in 610 Cambridge Centre for Ageing and Neuroscience (Cam-CAN) Healthy Participants

Te-Wei Kao1, Yung-Chin Hsu2, and Wen-Yih Isaac Tseng1,3

1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2AcroViz Technology, Inc., Taipei, Taiwan, 3Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

Previous studies did not clearly characterize normal ageing patterns of white matter tracts across lifespan. Here, we performed tract-specific automatic analysis over the whole brain to measure the diffusion indices on 610 healthy participants recruited from Cam-CAN. We used quadratic or linear models to plot the curves of diffusion indices against age, and calculated the average values and slopes of the curves in 10 subsystems classified from 76 major tracts. Our study characterized different ageing patterns corresponding to different subsystems.

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