Abstract #0334

Evaluation of standardized as well as study-specific and age-specific structural T1-weighted brain templates for use in studies on older adults

Abdur Raquib Ridwan¹, Shengwei Zhang¹, Mohammad Rakeen Niaz¹, Xiaoxiao Qi¹, David A. Bennett², Yongyi Yang¹, and Konstantinos Arfanakis^1,2

¹Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer’s Disease Center, Rush University, Chicago, IL, United States

Atlas-based MRI investigations on older adults often utilize young adult standardized templates, such as those of the ICBM. Additionally, a thorough, quantitative assessment of how available standardized, study-specific and age-specific structural templates perform in studies on older adults has not yet been conducted. Here, a new standardized T1-weighted template was developed specifically for studies on older adults, and was compared to 25 other standardized, study-specific, and age-specific templates, in terms of image quality and inter-subject spatial normalization accuracy.

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