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Abstract #0334

Evaluation of standardized as well as study-specific and age-specific structural T1-weighted brain templates for use in studies on older adults

Abdur Raquib Ridwan1, Shengwei Zhang1, Mohammad Rakeen Niaz1, Xiaoxiao Qi1, David A. Bennett2, Yongyi Yang1, and Konstantinos Arfanakis1,2

1Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer’s Disease Center, Rush University, Chicago, IL, United States

Atlas-based MRI investigations on older adults often utilize young adult standardized templates, such as those of the ICBM. Additionally, a thorough, quantitative assessment of how available standardized, study-specific and age-specific structural templates perform in studies on older adults has not yet been conducted. Here, a new standardized T1-weighted template was developed specifically for studies on older adults, and was compared to 25 other standardized, study-specific, and age-specific templates, in terms of image quality and inter-subject spatial normalization accuracy.

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