Functional connectivity of select resting state networks has been shown to diminish with age. Reported observations of reductions in visual and salience network strength appear to be supported by findings of vulnerability of the associated parietal, occipital, and frontal lobes to structural changes in the healthy brain.
We present data suggesting that measures of R2* in parietal and frontal lobar regions are correlated to visual and salience network connectivity in healthy individuals. These observations may indicate that early breakdown in myelin, associated with R2* shortening in white matter, may be responsible for age related decline in these resting state networks.
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