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Abstract #0339

Reduced functional connectivity of resting state networks in the healthy brain is associated with R2*changes consistent with myelin breakdown

James O'Callaghan1, Lysia Demetriou1, Ayla Mansur1, Adam Connolly1, Mari Lambrechts1, Simon Daniel Robinson2, Korbinian Eckstein2, Lefkos Middleton3, Matthew Wall1, Courtney Bishop1, Roger Gunn1, and Eugenii Rabiner1

1Invicro, London, United Kingdom, 2High Field MR Centre, Medical University of Vienna, Vienna, Austria, 3AGE Research Unit, Imperial College London, London, United Kingdom

Functional connectivity of select resting state networks has been shown to diminish with age. Reported observations of reductions in visual and salience network strength appear to be supported by findings of vulnerability of the associated parietal, occipital, and frontal lobes to structural changes in the healthy brain.

We present data suggesting that measures of R2* in parietal and frontal lobar regions are correlated to visual and salience network connectivity in healthy individuals. These observations may indicate that early breakdown in myelin, associated with R2* shortening in white matter, may be responsible for age related decline in these resting state networks.

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