Abstract #0341

The Relationship between Glutamate and BOLD signal changes During Face-Name Paired-Associates Encoding and Retrieval Memory Task in Healthy Adults concerning age, performance level and genetic risk-A combined 1H-MRS and fMRI study

Hui Zhang¹, PW Chiu^1,2, SWH Wong³, GHY Wong⁴, T Liu⁴, Q Chan⁵, and HKF Mak^1,2,6

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Educational Psychology, Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Social Work and Administration, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Philips Healthcare, Hong Kong, Hong Kong, ⁶Alzheimer's Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong

Glutamate is hypothesized to be the neurotransmitter in mediating BOLD fMRI. In this study, fMRI technique was combined with Magnetic Resonance Spectroscopy(MRS) to investigate the relationship between glutamate and the BOLD signal changes during face-name memory task. Three different task-based fMRI face name memory experiments were performed respectively focusing on age difference, performance level and genetic risk. [Glx]_abs in left hippocampus of elderly(Experiment1), high-performance(Experiment2) and low genetic risk(Experiment3) showed high correlation with BOLD signal changes in activated regions. On the whole, glutamate appears to be excitatory and lead to compensatory excitations.

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