Abstract #0343

Evaluating microstructure of the corticospinal tract in normal pressure hydrocephalus with diffusion MRI using oscillating gradient spin-echo

Ryusuke Irie^1,2, Kouhei Kamiya², Masaaki Hori¹, Michimasa Suzuki¹, Koji Kamagata¹, Tomoko Maekawa^1,2, Shohei Fujita^1,2, Yuki Takenaka³, Issei Fukunaga¹, Madoka Nakajima⁴, Masakazu Miyajima⁵, Katsutoshi Murata⁶, and Shigeki Aoki¹

¹Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ³Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ⁴Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan, ⁵Neurosurgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan, ⁶Siemens Healthcare K.K., Tokyo, Japan

We evaluated the corticospinal tract (CST) of normal pressure hydrocephalus (NPH) patients using the oscillating gradient spin-echo (OGSE) method. Diffusion time can be reduced greatly with OGSE and properties of the microstructure can be evaluated in more detail by collecting data using multiple diffusion times. The diffusivity of the CST increased and the diffusion time dependence was small in NPH patients compared with healthy controls. It is possible to estimate the structural change of CST in NPH by using multiple diffusion times with OGSE.

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