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Abstract #0350

Cholesteatomas Detection using PSF-encoded EPI DWI

Guangqi Li1, Yishi Wang1,2, Yingying Shang3, Yufei Qiao3, and Hua Guo1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Philips Healthcare, Beijing, China, 3Department of Otorhinolaryngology, Peking Union Medical College Hospital, Beijing, China

DWI has proved to be valuable in detection of cholesteatoma, but there still remain challenges. Susceptibility artifacts and geometric distortions in single-shot EPI DWI affect the identification of subtle nidus. TSE-based DWI can reduce susceptibility-induced artifacts, but the disadvantages are SNR degradation and T2-blurring. In this work, point-spread-function (PSF) encoded EPI DWI was employed to overcome the aforementioned limitations for cholesteatomas detection. This technique has the capability to acquire high-quality, distortion- and blurring-free diffusion images with more accurate lesion boundary.

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