Abstract #0350

Cholesteatomas Detection using PSF-encoded EPI DWI

Guangqi Li¹, Yishi Wang^1,2, Yingying Shang³, Yufei Qiao³, and Hua Guo¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²Philips Healthcare, Beijing, China, ³Department of Otorhinolaryngology, Peking Union Medical College Hospital, Beijing, China

DWI has proved to be valuable in detection of cholesteatoma, but there still remain challenges. Susceptibility artifacts and geometric distortions in single-shot EPI DWI affect the identification of subtle nidus. TSE-based DWI can reduce susceptibility-induced artifacts, but the disadvantages are SNR degradation and T2-blurring. In this work, point-spread-function (PSF) encoded EPI DWI was employed to overcome the aforementioned limitations for cholesteatomas detection. This technique has the capability to acquire high-quality, distortion- and blurring-free diffusion images with more accurate lesion boundary.

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