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Abstract #0354

Diffusion kurtosis imaging in quantitative diagnosis of nonalcoholic fatty liver disease: a rabbit model study

Xianfu Luo1, Chang li1,2, Weiqiang Dou3, Yun Peng2, and Jing Ye1

1Department of radiology, Clinical Medical School of Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou, China, 2XiangYa school of medicine, Central South University, Changsha, China, 3GE Healthcare,MR Research China, beijing, China

We aimed to investigate if diffusion kurtosis imaging (DKI) can be applied to assess nonalcoholic fatty liver disease (NAFLD) by providing fractional anisotropy (FA), mean diffusion (MD) and mean kurtosis (MK). We used DKI derived parameters to analyze NAFLD in a rabbit model and compared them with the apparent-diffusion-coefficient (ADC) from a mono-exponential diffusion-weighted imaging model. While FA showed comparable results with the severity of NAFLD group, MD and MK indicated more robust performance in the diagnosis of nonalcoholic steatohepatitis (NASH) compared with ADC. We therefore demonstrated that DKI had potential in stratifying NAFLD and early diagnosis of NASH.

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