Abstract #0366

Measuring layer-dependent CBV fMRI in the visual system

Laurentius Huber¹, Elisha Merriam¹, Insub Kim², Yuhui Chai¹, Sriranga Kashyap³, Jonathan Polimeni⁴, Zvi Roth¹, Won Mok Shim², Seong-Gi Kim², Dimo Ivanov³, Benedikt Poser³, and Peter Bandettini¹

¹NIH, Bethesda, MD, United States, ²IBS Center, Sungkyunkwan, Korea, Republic of, ³MBIC, Maastricht University, Maastricht, Netherlands, ⁴MGH, Boston, MA, United States

With recent developments of ultra-high field MRI and high-resolution CBV-sensitive VASO sequences, it became possible to measure activity changes across cortical depths in brain areas of large cortical thicknesses (4mm in M1). Applications of layer-dependent CBV-fMRI in the visual cortex, however, have been complicated by long arterial-arrival-times, coverage requirements, and lower cortical thickness (1.9mm). Here, we developed new sequence setups for layer-dependent acquisition of CBV changes during tasks and resting-state. We find that the proposed large-coverage VASO protocols with 0.8mm (iso) resolutions can pinpoint feedforward and feedback input into V1 from LGN and V5 during tasks and resting-state.

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