Abstract #0368

Comparison of SMS-EPI versus 3D-EPI in an fMRI localizer study at HCP-style resolution and TR, using parallel transmission Universal Pulses at 7T

Caroline Le Ster¹, Franck Mauconduit², Antonio Moreno³, Vincent Gras¹, Rüdiger Stirnberg⁴, Benedikt A Poser⁵, Alexandre Vignaud¹, Evelyn Eger³, Florent Meyniel³, Stanislas Dehaene^3,6, and Nicolas Boulant¹

¹Neurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France, ²Siemens Healthineers, Saint-Denis, France, ³Neurospin, CEA, Université Paris-Saclay, INSERM, Gif-sur-Yvette, France, ⁴German Center for neurodegenerative diseases (DZNE), Bonn, Germany, ⁵Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, ⁶Collège de France, Paris, France

Simultaneous-Multi-Slice (SMS) and 3D-EPI sequences with parallel-transmit B1 homogenization by means of calibration-free Universal Pulses were evaluated at 7T and at HCP-style resolution and repetition time (1.6mm iso, TR=1120ms). Comparison was based on sensitivity and specificity of activation detection in a multi-modal functional localizer task paradigm. When including nuisance regressors in the analysis, the SMS-EPI shows superior sensitivity but lower specificity than the 3D-EPI, with overall comparable performance when weighting the two metrics equally, but with significantly smaller SAR demands and sound pressure levels for the 3D-EPI.

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