Abstract #0376

Peri-tumoral radiomics on 3T MRI discriminative of D’Amico prostate cancer risk categories show association with epithelium, lumen and stromal densities on whole mount pathology

Rakesh Shiradkar¹, Ahmad Algohary¹, Xavier Farre², Patrick Leo¹, Harri Merisaari³, Pekka Taimen⁴, Hannu J Aronen³, Peter J Bostrom⁴, Ivan Jambor^3,5, and Anant Madabhushi¹

¹Case Western Reserve University, Cleveland, OH, United States, ²Self-employed, Lleida, Spain, ³University of Turku, Turku, Finland, ⁴Turku University Hospital, Turku, Finland, ⁵Icahn School of Medicine at Mount Sinai, New York, NY, United States

There is currently increasing interest in looking at role of radiomic features within the peri-tumoral region for disease characterization. In this work, we explore association of peri-tumoral radiomic features of prostate extracted from mpMRI with D’Amico risk. Additionally, we explore morphologic basis of these peri-tumoral features by analyzing the region on whole mount pathology. We observed greater epithelial content in high-risk compared to low, intermediate-risk lesions and vice versa with stroma. This heterogeneity within the peri-tumoral region may be captured by radiomic features that suggest peri-tumoral region of prostate may contain important information associated with risk of prostate cancer progression.

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