There is currently increasing interest in looking at role of radiomic features within the peri-tumoral region for disease characterization. In this work, we explore association of peri-tumoral radiomic features of prostate extracted from mpMRI with D’Amico risk. Additionally, we explore morphologic basis of these peri-tumoral features by analyzing the region on whole mount pathology. We observed greater epithelial content in high-risk compared to low, intermediate-risk lesions and vice versa with stroma. This heterogeneity within the peri-tumoral region may be captured by radiomic features that suggest peri-tumoral region of prostate may contain important information associated with risk of prostate cancer progression.
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