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Abstract #0376

Peri-tumoral radiomics on 3T MRI discriminative of D’Amico prostate cancer risk categories show association with epithelium, lumen and stromal densities on whole mount pathology

Rakesh Shiradkar1, Ahmad Algohary1, Xavier Farre2, Patrick Leo1, Harri Merisaari3, Pekka Taimen4, Hannu J Aronen3, Peter J Bostrom4, Ivan Jambor3,5, and Anant Madabhushi1

1Case Western Reserve University, Cleveland, OH, United States, 2Self-employed, Lleida, Spain, 3University of Turku, Turku, Finland, 4Turku University Hospital, Turku, Finland, 5Icahn School of Medicine at Mount Sinai, New York, NY, United States

There is currently increasing interest in looking at role of radiomic features within the peri-tumoral region for disease characterization. In this work, we explore association of peri-tumoral radiomic features of prostate extracted from mpMRI with D’Amico risk. Additionally, we explore morphologic basis of these peri-tumoral features by analyzing the region on whole mount pathology. We observed greater epithelial content in high-risk compared to low, intermediate-risk lesions and vice versa with stroma. This heterogeneity within the peri-tumoral region may be captured by radiomic features that suggest peri-tumoral region of prostate may contain important information associated with risk of prostate cancer progression.

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