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Abstract #0394

Evaluation of Single Bolus, Multi-Echo Dynamic Susceptibility Contrast Protocols in Brain Tumor Patients

Ashley M Stokes1, Ashley Nespodzany1, Lea Alhilali2, Leland Hu3, C. Chad Quarles1, and Leslie C. Baxter1

1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States, 2Radiology, Barrow Neurological Institute, Phoenix, AZ, United States, 3Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ, United States

Relative cerebral blood volume (rCBV) obtained from dynamic susceptibility contrast (DSC) MRI is adversely impacted by contrast agent leakage in brain tumors. Using a digital reference object, we previously demonstrated that multi-echo DSC-MRI protocols provide advantages in terms of contrast agent dosing, pulse sequence flexibility, and rCBV accuracy. The purpose of this study is to assess the in-vivo performance of multi-echo acquisitions in patients with brain tumors. Multi-echo rCBV obtained without a preload is compared to the standard single-echo rCBV obtained with preload. In addition, two contrast agent doses and two flip angles are compared for the multi-echo acquisition.

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